SGLT2 inhibitors were chosen as the comparator given they are guideline-recommended second-line glucose-lowering medication and share similar cardiovascular benefits with GLP-1RA, which helps reduce confounding by indication
Conversely, higher concentrations of NT in the NAc increase dopamine release, which may be mediated by NTS1 on presynaptic dopaminergic terminals, and would be predicted to enhance the effects of psychostimulants (Figure 2A) (Reyneke et al., 1990
Stavridou E, Michailidis M, Gedeon S, Ioakeim A, Kostas S, Chronopoulou E, Labrou NE, Edwards R, Day A, Nianiou-Obeidat I, Madesis P (2019) Tolerance of transplastomic tobacco plants over-expressing a theta class glutathione transferase to abiotic and oxidative stresses
Return of Appetite As semaglutide leaves your system, appetite suppression ends